Leader of the Sirius Marksmen, a group of exorcists who had banished evil in various forms since ancient times, Claudio Serafino was one of the most powerful exorcists in his organization.

After learning from Heihachi Mishima six months earlier of Jin Kazama and Kazuya Mishima, and the power they command over the devil gene, Claudio decided to cooperate with Heihachi despite considerable opposition from within his own organization.

Also, Claudio learned of the existence of Ling Xiaoyu who was searching for Jin. He decided to get close to Xiaoyu in order to use her in his mission to locate and defeat Jin. Born in to the house of the "purifying blue flame", Claudio took pride in his lineage, and was determined to defeat Devil at all cost.

However, Claudio lost all credibility due to a certain incident in which Heihachi betrayed him, and dissolved their cooperative alliance.

Many of the organization's members defected to save themselves, causing Claudio great distress. In this difficult time, Xiaoyu and her undying trust in Jin Kazama left a strong impression on him.

Claudio, embarrassed by his actions up to that point, confessed everything to Xiaoyu and apologized. He promised to aid her in her quest to find Jin.

However, if Jin were overcome by the influence of the Devil gene and betrayed Xiaoyu, Claudio would have no reservations about what he must do...

Determined to do what he must, Claudio released one of the seals on his right arm. It was the forbidden exorcism arts that had been forbidden by his those before him, as its power consumes the lifeforce of its practitioner.